• Study objectives
• How the study works
• What you will be asked to do if you agree to participate
• Participation
• Note
• Investigators

» Study Objectives

1. To determine if the study vaccine will provide protection against herpes zoster (shingles) viral infection
2. To help determine how well this vaccine is tolerated by people with weakened immunity

» How the study works

To participate you must

1. Be 18 years or older
2. Be getting a bone marrow or stem cell transplant
3. Have a cancer of the blood (leukemia, lymphoma, or multiple myeloma) and be receiving chemotherapy
4. Have breast, lung, or colorectal cancer and be receiving chemotherapy

You must not

1. Be pregnant or breastfeeding
2. Have had shingles in the past 12 months
3. Ever received chickenpox or shingles vaccine

» What you will be asked to do if you agree to participate

1. 5 appointments at Mount Sinai Hospital over a 5-month period
2. Injection of study vaccine once monthly for 4 months
3. Blood samples once every month for 5 months
4. Record of daily temperature, medications, and bad effects in a study diary

» Participation

If you would like to learn more about the study, please email idresearch@mtsinai.on.ca

Or call Lorraine at 416-586-4800 ext. 2764

» Note

People with weakened immune systems

1. Are more likely to have severe complications from shingles
2. Cannot receive the standard herpes zoster vaccine

» Investigators

Dr. Allison McGeer

Dr. Jeffery Lipton

Dr. Dominick Amato