Publications
| Comparative In Vitro Activity of Beta-Lactams, Macrolides, Fluoroquinolones and Ketolides against Respiratory Pathogens in Quebec in 2002. |
Authors: K. Weiss, C. Restieri, M. Cayouette, P. Dolce, L.A. Galarneau, C. Laferriere, I. Lecorre, M. Libman, J.F. Paradis, H. Senay, C. Tremblay, P. Vigeant, D.E. Low.
Background: Increasing resistance among respiratory pathogens is a growing challenge for clinicians. Continuous monitoring of resistance levels is necessary in order to optimise therapy.
Method: Throughout a surveillance network covering the whole province (17 centers), we have collected and tested all Streptococcus pneumoniae (Sp), Hemophilus influenzae (Hi) and 100 Moraxella catarrhalis isolated in these centers from 1 October 2001 to 31 March 2002. 407 Sp (295 non-invasive,112 invasive) were collected during this period. For Sp, 250 strains were isolated from men, 157 from women. 291 (71.5%) came from patients 16 and over.
Results: For Mc, the % of beta-lactamase producing strains was 79.6 %. All the other antibiotics were very active against Mc strains.
Conclusions: Resistance levels to all classes of antibiotics were stable compared to the previous year. There was a significant difference in terms of resistance to macrolides and beta-lactams between metropolitan areas and other areas in spite of similar antibiotics consumption. New ketolides (ABT-773 and telithromycin) showed great in vitro activity against Sp strains resistant to macrolides.
Presented At:
42nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, California, 9/27/2002.
|
|
|
|
|
©Copyright
1999 Microbiology Department, Mount Sinai Hospital, Toronto, ON, Canada.
All rights reserved. Last Modified
|
|
