Publications
| In Vitro Activity of Several Agents against Recent Blood Isolates of Coagulase-Negative Staphylococci (CNST) from Greater Toronto Area (GTA) Hospitals. |
Authors: B.M. Willey, A. Shigayeva, S. Pong-Porter, Y. Rzayev, K. Green, Canadian Bacterial Surveillance Network, Toronto Invasive Diseases Network, D.E. Low.
Background: CNST continue to be an important cause of blood stream infections and infections of implanted foreign devises. This study compared daptomycin, quinupristin/dalfopristin (synercid) and linezolid to commonly used antibiotics against consecutive but diverse methicillin-resistant (MR) and methicillin-susceptible (MS) CNST.
Method: The 206 CNST, isolated between 2000 and 2003 from patients in 11 GTA hospitals, were tested by NCCLS broth microdilution to the antimicrobials listed below. NCCLS breakpoints were used when available, otherwise for this study we used the following susceptible (S), intermediate (I), and resistant (R) breakpoints for: fusidic acid, <=1 (S), 2 (I), >=4 (R); mupirocin, low-level R (8-256g/mL) and high-level R, >256g/mL daptomycin; S, <=2g/mL.
Results: The MIC distribution frequencies in ug/mL and percentage (%)-R are as follows:
Conclusions: As has been noted by others, there is high prevalence of resistance to first- and second-line anti-staphylococcal agents. However, newer agents such as daptomycin, synercid and linezolid have excellent activity against both MS- and MR-CNST.
Presented At:
43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, Illinois, 9/14/2003.
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1999 Microbiology Department, Mount Sinai Hospital, Toronto, ON, Canada.
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