TML & MSH Department of Microbiology: MicroWeb

Daneman N, Green KA, Low DE, Simor AE, Willey B, Schwartz B, Toye B, Jessamine P, Tyrrell GJ, Krajden S, Ramage L, Rose D, Schertzberg R, Bragg D, McGeer A; Ontario Group A Streptococcal Study Group. Surveillance for hospital outbreaks of invasive group A streptococcal infections in Ontario, Canada, 1992 to 2000. Ann Int Med. 147(4):234-41, 8/21/2007.
Mehta S, McGeer A, Low DE, Hallett D, Bowman DJ, Grossman SL, Stewart TE. Morbidity and mortality of patients with invasive group A streptococcal infections admitted to the ICU. Chest 130(6):1679-86., 12/1/2006.
Valiquette L, Low DE, Chow R, McGeer AJ. A survey of physician's attitudes regarding management of severe group A streptococcal infections. Scand J Infect Diseases. 38(11-12):977-82., 11/1/2006.
Thulin P, Johansson L, Low DE, Gan BS, Kotb M, McGeer A, Norrby-Teglund A. Viable Group A Streptococci in Macrophages during Acute Soft Tissue Infection. PLoS Med. 17;3(3):e53, 1/17/2006.
Salim KY, Cvitkovitch DG, Chang P, Bast DJ, Handfield M, Hillman JD, de Azavedo JC. Identification of group A Streptococcus antigenic determinants upregulated in vivo. Infect Immun. 73(9):6026-6038., 9/1/2005.
Daneman N, McGeer A, Low DE, Tyrrell G, Simor AE, McArthur M, Schwartz B, Jessamine P, Croxford R, Green KA; Ontario Group A Streptococcal Study Group. Hospital-acquired invasive group a streptococcal infections in Ontario, Canada, 1992-2000. Clin Infect Dis. 41(3):334-342., 8/1/2005.
Green NM, Beres SB, Graviss EA, Allison JE, McGeer AJ, Vuopio-Varkila J, LeFebvre RB, Musser JM. Genetic diversity among type emm28 group A Streptococcus strains causing invasive infections and pharyngitis. J Clin Microbiol. 43(8):4083-4091., 8/1/2005.
Factor SH, Levine OS, Harrison LH, Farley MM, McGeer A, Skoff T, Wright C, Schwartz B, Schuchat A. Risk factors for pediatric invasive group A streptococcal disease. Emerg Infect Dis. 11(7):1062-1066., 7/1/2005.
Norrby-Teglund A, Muller MP, Mcgeer A, Gan BS, Guru V, Bohnen J, Thulin P, Low DE. Successful management of severe group A streptococcal soft tissue infections using an aggressive medical regimen including intravenous polyspecific immunoglobulin together with a conservative surgical approach. Scand J Infect Diseases. 37(3):166-172., 3/1/2005.
Aziz RK, Pabst MJ, Jeng A, Kansal R, Low DE, Nizet V, Kotb M. Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB. Mol. Microbiol. 51(1):123-134, 1/1/2004.

Conference Presentations

A.M. Morris, A. McGeer, R. Davis, and D.E. Low for the Ontario Group A Streptococcal Study Group. Survival of Bacteremic Group A Streptococcal Infection in Ontario, Canada 1992-96. 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

A.M. Morris, R. Davis, J. Dedier, B. Garcia-Pena, M. Loeb, A. Schuchat and A. McGeer for the Toronto Invasive Bacterial Diseases Network. Survival of Bacteremic Pneumococcal Pneumonia in Toronto, Ontario 1995-98. 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

A. Norrby-Teglund, B.S. Gan, M. Kotb, J. Andersson, A. McGeer, D.E. Low. Massive Bacterial Load and In Vivo Expression of Superantigen (SAg) in Patients with Severe Tissue Infections Caused by Group A Streptococci (GAS). 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

A. R.G. Kansal, A. McGeer, D.E. Low, M. Kotb. Inverse Relation Between Disease Severity and Expression of the Streptococcal Cysteine Protease, SpeB, among Clonal M1T1 Isolates Recovered from Invasive Group A Streptococcal Infection Cases. 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

M. Kotb, A. Norrby-Teglund, A. McGeer, J. Peeples, A Khurshid, Y. Guedez, K. Green, D.E. Low. Distinct HLA Haplotypes are Associated with Different Outcomes of Invasive Streptococcal Infections. 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

M.P. Mueller, A.J. McGeer, D.E. Low, The Ontario Group A Streptococcus Study. Clinical and Epidemiological Features of Group A Streptococcal (GAS) Pneumonia in Ontario, Canada: 1992 to 1996. 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

R. Lovinsky, D.E. Low, J.C.S. deAzavedo, L. Trpeski, M. Lovgren, G. Tyrrell, B.M. Willey, S. Pong-Porter, A. McGeer. Ontario Group A Streptococcal Study Group. Reduced ketolide susceptibility in clinical group A streptococci (GAS) in Ontario, Canada. 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 12/16/2001.

K.C. Katz, A. McGeer, C.L. Duncan, B. Willey, A. Sarabia, J. McCann, S. Pong-Porter, Y. Rzayev, J.S. De Azavedo, D.E. Low. Increasing Prevalence of Macrolide Resistance (MR) in Community Acquired Pharyngeal Isolates of Group a Streptococci (GAS) from Ontario, Canada. 42nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, California. 9/27/2002.

J.D. Kellner, P. Aufricht, W.J. McIsaac, L. Bucholtz, A. Vanjaka, D.E. Low. Use of Both a Clinical Score and Rapid Antigen Test Improves the Bedside Diagnostic Accuracy to Detect Group A Streptococcus (GAS) Sore Throats. 42nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, California. 9/27/2002.

N. Daneman, A. McGeer, D.E. Low, M. McArthur, A. Plevneshi, P. Jessamine, K. Green. Nosocomial Invasive Group A Streptococcal Infections in Ontario. 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 9/14/2003.

N. Daneman, A. Mcgeer, D. Low, A. Plevneshi, K. Green Nosocomial Invasive Group A Streptococcal Infections in Ontario 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. 12/16/2005.

S. J. DREWS, S. M. POUTANEN, A. J. MCGEER, T. MAZZULLI, R. LOVINSKY, J. POWIS, K. GREEN, Y. RZAYEV, S. PONG-PORTER, D. E. LOW, Ontario Invasive Gas Study Group; Toronto Med. Lab. and Mount Sinai Hosp., Toronto, Canada. Emergence of Erythromycin-Resistance (Ery-R) in Invasive Group A Streptococci (IGAS) from Ontario, Canada: (1993-2003) 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. 12/16/2005.

S. CHATELLIER*, F. KHAMBATY, H. BASMA, Y. GUEDEZ, A. NORRBY-TEGLUND, L. TRPESKY, D.E. LOW, A. MCGEER, and M. KOTB, VA Med. Ctr., Memphis, TN, U.S. FDA, Washington, DC, Mount Sinai Hosp., Toronto, Canada, Univ. of TN, Memphis, TN. Variation in Severity of Invasive Group A Streptococcal Infections Caused by Genotypically Indistinguishable M1T1 Strains. 38th Interscience Conference On Antimicrobial Agents and Chemotherapy. San Diego, CA. 9/26/1998.

D. J. BAST, V. NIZET, B. BEALL, V. DATTA, D. E. LOW, AND J. C. S. DE AZAVEDO. Department of Microbiology, Mount Sinai and Princess Margaret Hospitals, 600 University Avenue, Toronto, Ontario, Canada, M5G 1X5; University of California, San Diego, California, USA; Centers for Disease Control, Atlanta, Georgia, USA. A Gene Cluster Required For Streptolysin S Production In Group A Streptococcus 39th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco. 9/26/1999.

C. Lee, D.E. Low, J. De Azavedo, L. Trpeski, M. Lovgren, G. Tyrrell, B.M. Willey, S. Pong-Porter, A. McGeer. Univ. of Toronto, Toronto, ONT, CANADA; Mount Sinai Hosp., Toronto, ONT, CANADA; Natl. Ctr. for Streptococcus, Edmonton, ALB, CANADA; Ontario Group A Streptococal Study, Toronto, ONT, CANADA. Lack of Association between Macrolide Use and the Emergence of Erythromycin Resistance (EryR) in Group A Streptococci Causing Invasive Disease in Onatario, Canada, 1992-1998. 39th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco. 9/26/1999.

A. Sharkawy, R. Saginur, D.E. Low, B. Schwartz, K. Green, G. Tyrrell, M. Lovgren, A. McGeer, L. Trpeski. Soft-Tissue Infections (STI) Due to Group A Streptococci (GAS) in Ontario, Canada, 1992-96: Clinical Features and Risk Factors for Severe Disease. 39th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco. 9/26/1999.

D. LIBERTUCCI, B. M. WILLEY, A. BERNSTON, G. TYRRELL, M. LOVGREN, S. PONG-PORTER, D. E. LOW, The Group A Streptococcal Study Group, A. MCGEER. Mount Sinai and Princess Margaret Hospitals, University of Toronto, Ontario; and The National Center for Streptococcus (NCS), Edmonton, Alberta. Association of M-Protein Type and Pulsed Field Gel Electrophoresis (PFGE) Pattern in Group A Streptococcus (GAS). 66th Conjoint Meeting on Infectious Diseases. Toronto, ON. 11/8/1998.

LOUIS VALIQUETTE, MD1, FRANÇOIS LAMONTAGNE, MD1, ALLISON J. MCGEER, MD2, KAREN GREEN, MS2, DONALD E. LOW, MD2, 1University de Sherbrooke, Sherbrooke, PQ, Canada, 2Mount Sinai Hospital, Toronto, ON, Canada. Invasive Group A Streptococcal (GAS) Infections in Ontario, Canada 1992-2001: The Experience of a Decade 44th Annual Meeting of the Infectious Diseases Society of America. Toronto, Ontario. 10/12/2006.

NICK DANEMAN, MD, KAREN GREEN, RN, Allison McGeer, MD, DONALD E. LOW, MD, Ontario Group A Streptococcal Study, Mount Sinai Hospital, Toronto, ON, Canada. Outbreaks of Nosocomial Invasive Group A Streptococcal Infections: Prospective Surveillance and Literature Review 44th Annual Meeting of the Infectious Diseases Society of America. Toronto, Ontario. 10/12/2006.