TML & MSH Department of Microbiology: MicroWeb

De Azavedo JC, Duncan CL, Kilburn L, Downar J, Kong B, Lad S, Low DE, Bast DJ. Relative potential for selection of quinolone-resistance-determining-region mutations in Streptococcus pneumoniae by gemifloxacin, gatifloxacin and moxifloxacin. J Chemother 18(4):373-8., 8/1/2006.
Lobbedez T, Gardam M, Dedier H, Burdzy D, Chu M, Izatt S, Bargman JM, Jassal SV, Vas S, Brunton J, Oreopoulos DG. Routine use of mupirocin at the peritoneal catheter exit site and mupirocin resistance: still low after 7 years. Nephrol Dial Transplant Epub ahead of print, 10/5/2004.
Karchmer, A.W. Increased Antibiotic Resistance in Respiratory Tract Pathogens: PROTEKT US - An Update Clin Infect Dis. 39(Suppl3):S142-S150, 9/1/2004.
Powis J, McGeer A, Green K, Vanderkooi O, Weiss K, Zhanel G, Mazzulli T, Kuhn M, Church D, Davidson R, Forward K, Hoban D, Simor A, Low DE; Canadian Bacterial Surveillance Network. In vitro antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates obtained in Canada in 2002. Antimicrob Agents Chemother. 48(9):3305-3311, 9/1/2004.
Low DE, Felmingham D, Brown SD, Rangaraju M, Nusrat R Activity of telithromycin against key pathogens associated with community-acquired respiratory tract infections. J Infect Dis. 49(2):115-125, 8/1/2004.
Boyd DA, Tyler S, Christianson S, McGeer A, Muller MP, Willey BM, Bryce E, Gardam M, Nordmann P, Mulvey MR. Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum beta-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada. Antimicrob Agents Chemother. 48(10):3758-3764, 8/1/2004.
Athamna A, Athamna M, Abu-Rashed N, Medlej B, Bast DJ, Rubinstein E. Selection of Bacillus anthracis isolates resistant to antibiotics. J Antimicrob Chemother. 54(2):424-8, 8/1/2004.
Sandoval C, Walter SD, McGeer A, Simor AE, Bradley SF, Moss LM, Loeb MB. Nursing home residents and Enterobacteriaceae resistant to third-generation cephalosporins. Emerg Infect Dis. 10(6):1050-1055, 6/1/2004.
Athamna A, Athamna M, Medlej B, Bast DJ, Rubinstein E. In vitro post-antibiotic effect of fluoroquinolones, macrolides, beta-lactams, tetracyclines, vancomycin, clindamycin, linezolid, chloramphenicol, quinupristin/dalfopristin and rifampicin on Bacillus anthracis. J Antimicrob Chemother. 53(4):609-615, 4/1/2004.
Loeb M, McGeer A, Simor A, Walter SD, Bradley S, Low DE, Moss L. Facility-level correlates of antimicrobial use in nursing homes. Inf Con & Hosp Epid. 25(2):173-176, 2/1/2004.

Conference Presentations

L. Kilburn, K. Salim, J. Downar, B. Tong, D.E. Low, D.J. Bast, J.C.S. deAzavedo. Moxifloxacin and gatifloxacin preferentially target GyrA in Streptococcus pneumoniae. 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

R.J. Davidson, J. De Azavedo, D. Bast, J. Arbique, R. Bethune, C. Duncan, A. McGeer, D.E. Low. The Activity of BMS-284756, a Novel Des-(6)F-Quinolone, Against Ciprofloxacin Susceptible and Non-susceptible Streptococcus pneumoniae. 40th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Toronto, Ontario. 9/17/2000.

K. Weiss, C. Restieri, P. Dolce, C. Laferriere, L. Lecorre, J.F. Paradis, H. Senay, D.E. Low. Increasing resistance of Streptococcus pneumoniae to ciprofloxacin in the Province of Quebec, Canada. 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 12/16/2001.

K. Weiss, C. Restieri, H. Guay, P. Dolce, C. Laferriere, L. Lecorre, J.F. Paradis, H. Senay, and the GRAM NETWORK, D.E. Low. A multi-center study comparing the activity of a novel ketolide ABT-773 with µ-lactams, macrolides and fluoroquinolones against respiratory tract pathogens isolated in 2000-2001 in the Province of Quebec, Canada. 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 12/16/2001.

D.C. Richardson, R.J. Davidson, L.A. Mandell, K. Weiss, D. Bast, J. deAzavedo, D.E. Low. Comparative in vitro activity of four respiratory fluoroquinolones (Resp-FQ) against clinical isoltes of strains of Streptococcus pneumoniae (SP). 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 12/16/2001.

J.S. DeAzavedo, M. Aquino, C.L. Duncan, M. Yue, D.E. Low, D.J. Bast. Garenoxacin (Gar) Exhibits Potent Activity Against Genetically Constructed Resistant Strains Of Streptococcus pneumoniae (Sp). 42nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, California. 9/27/2002.

K. Weiss, C. Restieri, M. Cayouette, P. Dolce, L.A. Galarneau, C. Laferriere, I. Lecorre, M. Libman, J.F. Paradis, H. Senay, C. Tremblay, P. Vigeant, D.E. Low. Comparative In Vitro Activity of Beta-Lactams, Macrolides, Fluoroquinolones and Ketolides against Respiratory Pathogens in Quebec in 2002. 42nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, California. 9/27/2002.

J.C.S. DeAzavedo, G. Kong, C.L. Duncan, S. Pong-Porter, L.A. Mandell, D.E. Low, D.J. Bast. Evaluation of the Activity of Garenoxacin (GRN) Compared with Ciprofloxacin (CIP) Against Clinical Isolates of Escherichia coli Collected from Across Canada. 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 9/14/2003.

D.E. Low. Pneumococcal Resistance to Antibiotics: Mechanisms and Prevalence. 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 9/14/2003.

K. Weiss, C. Restieri, N. Jubinville, D.E. Low, and the EQUERE project. Streptococcus pneumoniae Resistance Levels to Beta-lactams, Macrolides, Fluoroquinolones and Ketolides in Quebec, Canada in 2003 : The Importance of Age. 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 9/14/2003.

B.M. Willey, A. Shigayeva, S. Pong-Porter, Y. Rzayev, K. Green, Canadian Bacterial Surveillance Network, Toronto Invasive Diseases Network, D.E. Low. In Vitro Activity of Several Agents against Recent Blood Isolates of Coagulase-Negative Staphylococci (CNST) from Greater Toronto Area (GTA) Hospitals. 43rd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, Illinois. 9/14/2003.

B.M.Willey, A.Shigayeva, S.Pong-Porter, Y.Rzayev, K.Green, D.E.Low. In Vitro Activity of Several Agents against Recent Blood Isolates of Coagulase-Negative Staphylococci (CNST) from Greater Toronto Area Hospitals 71st Conjoint Meeting on Infectious Diseases. Montreal, Quebec. 11/2/2003.

Adam B. Olson, M. Silverman, D.A. Boyd, A. McGeer, B. M. Willey, V. Pong-Porter, N. Daneman, M.R. Mulvey Identification of a progenitor of the CTX-M-9 group of extended-spectrum ß-lactamase from Kluyvera spp. 'Guyana'? 72nd Conjoint Meeting on Infectious Diseases. Regina, Saskatchewan. 11/7/2004.

C. OSIOWY*, A. CHATTERJEE, E. GILES, J. BORLANG, T. MAZZULLI, J. HEATHCOTE National Genotypic Analysis of Lamivudine-Resistant Hepatitis B Virus in Chronic Patients Following Withdrawal of Long Term Lamivudine Treatment 72nd Conjoint Meeting on Infectious Diseases. Regina, Saskatchewan. 11/7/2004.

N. Daneman, A. Mcgeer, D. Low, A. Plevneshi, K. Green Nosocomial Invasive Group A Streptococcal Infections in Ontario 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. 12/16/2005.

A. L. KWA, J. G. H. LOW, A. KURUP, V. H. TAM; Singapore Gen. Hosp., Spore, Singapore, Univ. of Houston, Houston, TX. Outcomes of Critically Ill Patients (CIP) with Gram-Negative Respiratory Tract Infections (GNRTI) 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. 12/16/2005.

A. L. KWA, Z. P. LIM, S. K. TAN, J. G. H. LOW, W. LEE, A. KURUP; Singapore Gen. Hosp., Spore, Singapore. Independent Predictors (IP) For Active (A) Stenotrophomonas maltophilia (SM) Infections (I) 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. 12/16/2005.

N. DANEMAN, K. A. GREEN, N. SIDDIQI, L. EUNSON, A. SHIGAYEVA, S. MILLER, A. PLEVNESHI, TORONTO INVASIVE BACTERIAL DISEASES NETWORK, A. MCGEER; University of Toronto, Toronto, ON, Canada, Mount Sinai Hospital, Toronto, ON, Canada. Antibiotic Use Prior to Pneumococcal Infections: Congruence of Patient and Physician Provided Antibiotic Histories 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Washington, DC. 12/16/2005.

B. M. WILLEY, D. BOYD, D. FAWCETT, N. GILLANI, J. PETO, K. PIKE, O. IMAS, M. LUM, C. LAROCQUE, I. DAVIS, M. MULVEY, A. MCGEER; Mount Sinai Hosp., Toronto, Canada, Natl. Microbiol. Lab., Winnipeg, Canada, Centenary Hosp., Toronto, Canada. A Poly-Clonal DHA-1 Outbreak Involving Klebsiella pneumoniae and Escherichia coli in a Toronto Community Hospital 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. San Francisco, CA. 9/27/2006.

Antimicrobial Activity

Conference Presentations